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Autoimmune hepatitis

Attack on the self

Aus unserer Serie »English Lesson«: In autoimmune hepatitis, the immune system recognises the body's own liver cells as foreign and attacks them with so-called autoantibodies. Acute or chronic hepatitis is the result.
Marta Campbell
09.08.2022  09:00 Uhr

The disease progresses to cirrhosis if left untreated. Liver cirrhosis is an irreversible stage and is reached in about half of those affected within 15 years of the onset of the disease. On the way to cirrhosis, the organ continuously loses functional tissue due to increasing scarring until it finally fails. In the final stage of AIH, only a liver transplant can save the patient's life. The disease also increases the risk of liver cancer.

It is not clear why the immune system attacks the liver in some people. It is possible that there is a genetic predisposition. Trigger factors such as viral and bacterial infections, drugs or toxins, together with impaired immune tolerance, could cause AIH to break out.

In some patients, the disease initially causes no or hardly any symptoms. Nonspecific symptoms such as fatigue, loss of appetite, nausea and vomiting or a feeling of pressure in the right upper abdomen may occur. However, AIH can also manifest itself as acute hepatitis with an icteric course. Typical signs are yellowing of the skin and eyes (jaundice), light-coloured stools, dark urine and itching. If the liver no longer performs its tasks adequately, this also becomes noticeable with disturbances of the metabolism, blood clotting and hormone balance. In women, menstruation may stop as a result of hormonal changes (amenorrhoea).

By Coincidence

Asymptomatic AIH is often an incidental finding. Routine examinations may reveal increased levels of aminotransferases (AST, ALT), prompting the doctor to further investigate. Other patients seek medical advice because they suddenly feel worse for no apparent reason. The diagnosis of AIH is complex and is best made by an experienced specialist. First, viral causes must be ruled out. Inflammation values, the level of antibodies of the type immunoglobulin G (IgG) in the blood as well as autoantibodies directed against liver cells provide indications of the disease. Based on the antibody spectrum, doctors distinguish between two types: AIH type 1 (formerly called lupoid hepatitis) is present in the majority of cases and occurs more frequently between the ages of 20 and 40. Patients usually respond well to drug therapy.

In about 10 per cent of cases, doctors diagnose AIH type 2. This type usually manifests itself in childhood or adolescence and its symptoms resemble acute hepatitis. The prognosis is worse. Four-fifths of patients develop cirrhosis during their lifetime. Some experts still distinguish a type 3, which resembles type 1.

AIH is not curable. However, medication can prevent that more and more liver tissue is destroyed. In remission, IgG and aminotransferases normalise. Immunosuppressants are the drugs of choice. They reduce the body's own immune system so that it can no longer attack the liver cells.

Mostly lifelong

The standard treatment is the combination of predniso(lo)n and azathioprine. Combination therapy has the advantage that the dose of glucocorticoids can be lower. Fewer side effects from these drugs also improve patient compliance. After one year of combination therapy, azathioprine alone may be sufficient to maintain remission.

For patients who do not respond to predniso(lo)n, budesonide is an alternative. It has the advantage of lower systemic glucocorticoid levels and thus fewer side effects due to a high hepatic first-pass effect. Its use can also be considered for maintenance therapy if there is a particular risk of steroid-related side effects. However, the prerequisite for administration is that the patient does not yet have cirrhosis.

People with AIH have to be prepared for long-term, usually permanent, pharmacotherapy. Only a few patients are able to stop taking the medication completely; in most cases, the inflammation flares up again. For long-term steroid therapy, the authors of the guideline recommend concomitant osteoporosis prophylaxis. Azathioprine can lead to blood count changes, and potential hepatotoxicity should also be considered. During regular check-ups, the doctor looks at the course of the disease in order to be able to intervene early in case of deterioration. With timely diagnosis and consistent treatment, the long-term prognosis for patients is good and they can expect an almost normal life expectancy.

However, some patients do not respond to the standard therapy. In these cases, the doctor may test other, less well-tested drugs from transplant medicine that are not approved for this indication, such as ciclosporin, tacrolimus or mycofenolate mofetil. If therapy fails completely, liver failure is imminent and organ transplantation is the last therapeutic option.

Deutsch/German Englisch/English
Abgeschlagenheit fatigue
Antikörper antibodies
Appetitlosigkeit loss of appetite
Autoantikörper autoantibodies
Autoimmunerkrankung autoimmune disease
Blutbild blood count
Diagnose diagnosis
Entzündung inflammation
Erbrechen vomiting
Hepatitis Hepatitis
Immunsuppressiva immunsuppressiva
Gelbsucht jaundice
Leber liver
Leberversagen liver failure
Leberzellen liver cells
Leberzirrhose liver cirrhosis
Müdigkeit tiredness, fatigue
Transplantation transplantation

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